Immunological exhaustion: How to make a disparate concept operational?

  by Hannah Kaminski, Maël Lemoine, Thomas Pradeu Published: September 23, 2021in PLoS PATHOGENS https://doi.org/10.1371/journal.ppat.1009892 Author summary In this essay, we have written a critical review on immunological exhaustion. We believe that this widely used concept often remains in fact imprecise because there exist 3 different approaches to exhaustion, namely, in terms of dysfunction, cause,… Read more »

Les ILC2 peuvent-elles jouer un rôle dans la fibrose au cours de la sclérodermie systémique ?

  Réponses en vidéo avec le Pr Marie-Élise TRUCHETET (Rhumatologue au CHU de Bordeaux, UMR CNRS 5164 ImmunoConcept), interviewée par le Pr Eric HACHULLA (Interniste au CHU de Lille et coordonnateur de la filière FAI²R). Interview à voir ici : https://www.fai2r.org/science-info/ilc2-fibrose-sclerodermie/ en lien avec le dernier article de l’équipe sur les ILC2 et la Sclérodermie… Read more »

The latest ILC & Systemic sclerosis paper

Have a look of the shining ILC2 paper in systemic sclerosis ! TGFβ promotes low IL10-producing ILC2 with profibrotic ability involved in skin fibrosis in systemic sclerosis Paôline Laurent, Benoit Allard ,Pauline Manicki, Valérie Jolivel, Emeline Levionnois, Mohamed Jeljeli, Pauline Henrot, Julien Izotte, Damien Leleu , Alexis Groppi, Julien Seneschal, Joel Constans, Carlo Chizzolini ,… Read more »

The latest gamma-delta T cell paper

The latest Gamma-delta T cell paper that involves several former students and post-docs of ImmunoConcEpT lab. Congrats for this achievement! Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2. Christelle Harly, Stephen Paul Joyce, Charlotte Domblides, Thomas Bachelet, Vincent Pitard, Charlotte Mannat, Angela Pappalardo, Lionel Couzi, Sonia Netzer, Layal Massara, Emilie Obre, Omar Hawchar, Lydia Lartigue, Stéphane Claverol, Carla Cano, Jean-François Moreau, Isabelle Mahouche, Isabelle Soubeyran, Rodrigue… Read more »

Two honored young researchers of ImmunoConcEpT

To launch his scientific career: Thomas Boyer was ranked #1 of the Doctoral School Competition 2021 (Sciences de la Vie et de la Santé). Thomas’ thesis will start in October 2021, on antitumor immunity, supervised by Nicolas Larmonier. Hannah Kaminski recieved “The Biology and Health” Price of the Graduate Research School (Collège des Ecoles Doctorales)… Read more »

Regards croisés sur le cancer,

  Charlotte Domblides et Victor Appay participeront à la prochaine édition des “Regards croisés”, organisée par le SIRIC-BRIO. RDV le 29/06/2021 à 18h pour « Le traitement adjuvant dans les cancers du poumon EGFR-mutés » et le 01/07/2021 à 18h pour « Le système immunitaire du patient âgé et son implication dans la prise en… Read more »

2 post-doc positions available in the Appay’s group

Two postdoctoral positions in Immunology are available at the “Vulnerability and Ageing of the Immune System” group within the ImmunoConcept Laboratory of the Bordeaux University, France under the supervision of Victor Appay. Start and Duration of the appointments: From October 2021 for 2 to 3years Complete information here.

May 17th: 1st Virtual Symposium in oncoimmunology UB-Munich LMU

The Universities of Bordeaux and Munich’s Ludwig Maximilians University organise their first virtual symposium in oncoimmunology on May 17th . The plenary sessions will be open to attendance from both universities. See the programme here. Login Details: https://lmu–munich.zoom.us/j/91217220569?pwd=VVRJd3gxR2hYc04xcCtBekhXeVFXdz09 Meeting–ID: 912 1722 0569 Kenncode: 996925

Two new reviews on Dnase1L3 !

The latest reviews of the Vanja Sisirak group on self-nucleic acid sensing! Self-Nucleic Acid Sensing: A NovelCrucial Pathway Involved in Obesity-Mediated Metaflammation andMetabolic Syndrome Amandine Ferriere, Pauline Santa, Anne Garreau, Purbita Bandopadhyay, Patrick Blanco, Dipyaman Ganguly and Vanja Sisirak Paper here ! The Role of Nucleases and Nucleic Acid Editing Enzymes in the Regulation of… Read more »