Category: Publication

CRISPR-Cas immunity: beyond nonself and defence

The journal Biology & Philosophy has published a special issue on the philosophy of CRISPR-Cas. Thomas Pradeu has written the introduction and together with Jean-François Moreau he presents a commentary to Eugene Koonin’s target paper. In the commentary Pradeu and Moreau defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot… Read more »

The epigenetics of inflammaging

New review in Seminars in Immunology. A growing amount of evidences indicates that inflammaging – the chronic, low grade inflammation state characteristic of the elderly – is the result of genetic as well as environmental or stochastic factors. In their latest review Christine Nadini, Jean-François Moreau, Noémie Gensous, Francesco Ravaioli, Paolo Garagnani and Maria Giulia… Read more »

The Multiple Layers of the Tumor Environment, new paper by Laplane et al

If and how a tumor develops, depends in large part on its surroundings. While scientists agree on the importance of the tumor environment (TE), there is no consensus on how to define and spatially delineate it. A new paper by Lucie Laplane, Dorothée Duluc, Nicolas Larmonier, Thomas Pradeu and Andreas Bikfalvi lays out six clearly… Read more »