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Jan 25th: Emmanuel Farge
25 January @ 14 h 30 min - 16 h 00 min UTC+1
Emmanuel Farge (Institut Curie)
« Mechanotransduction in development: from mesoderm mechanotransductive evolutionary origins to tumorigenic mechanical induction »
Bilaterians are complex organisms, characterized by the existence of a mesoderm tissue from which most of the animal’s complex organs develop. The lack of conservation of biochemical signalling proteins upstream of early embryonic mesoderm differentiation across bilaterians prevents to answer the question of the signal having been at the evolutionary origin of mesoderm emergence and complex animals. We found that the Y654 site of b-catenin to be implicated in earliest mesoderm differentiation in the vertebrate zebrafish and un-vertebrate Drosophila. Extended to tumor biology and cancer progression, we found mechanical activation of b-catenin to be conserved in mice and involved in the mechanical activation of tumorigenic biochemical pathways, in the healthy epithelium compressed by the neighboring tumour, in response to tumor growth pressure in vivo.
Emmanuel Farge is Research Director at INSERM, Mechanics and Genetics of Embryonic and Tumoral Development group, UMR 168 Physico-Chimie Curie, Institut Curie – Paris Sciences et Lettres Research University.