Oct 31th: Yonathan Arfi
31 October @ 13 h 30 min - 14 h 30 min UTC+1
UMR 1332 Biologie du Fruit et Pathologie
Title: Functional and structural analysis of the MIB-MIP antibody cleavage system and its associated atypical F-like ATPase
Abstract: Mycoplasma are small pathogenic bacteria, able to infect a large range of animal hosts, including humans and the majority of livestocks species. The host-pathogen interactions of these organisms are not well known, and previous data suggest a strong ability to evade the immune system through multiple stragies. Recently, we identified a large cluster of 15 genes, encoding multiple putative proteins of unknown function, including an atypical F1-ATPase. This cluster is found throughout the mycoplasma phylogenetic tree, in all the animal pathogenic species and some human pathogens. We have identified the function of some of these putative proteins: one is tasked with capturing immunoglobulins and to recruit the second, an immunoglobulin specific protease that cleaves the VH domain of the antibody. Through both functional and structural analysis, we attempt to better understand the function of this system, and its function during infection.