Authors: Marlin R*, Pappalardo A, Kaminski H, Willcox CR, Pitard V, Netzer S, Khairallah C*, Lomenech AM, Harly C, Bonneville M, Moreau JF, Scotet E, Willcox BE, Faustin B, Déchanet-Merville J.
Marlin & Pappalardo co-first authors
Proc Natl Acad Sci U S A. 2017 Mar 7. pii: 201621052. doi: 10.1073/pnas.1621052114
Photo: *Romain Marlin and Camille Khairallah, former CNRS UMR 5164 members.
Human γδ T lymphocytes have innate-like and adaptive-like functions and can circulate in blood or reside in tissues. They are activated by specific antigens recognized by their T-cell receptor and recognize infected and transformed cells, suggesting that cellular stress is involved in specific antigen expression. However, molecular characterization of stress-induced antigens remains elusive, hampering our understanding of the role of γδ T cells in cancer and infections. In the present study we identify annexin A2 as such stress-induced antigen known as a phospholipid-binding protein involved in tumorigenesis, redox potential regulation, and wound healing. Stress-mediated membrane exposure of annexin A2 could thus constitute a danger signal for γδ T cells to recognize various cell dysregulations and protect the host against cancer and infections.
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