Our research programs focus on the immune system and its pathologies and regroup most investigators involved in this field on the Bordeaux campus.

The immune system is dedicated to preserve the host integrity. When the latter is threatened by environmental pathogens or by abnormal cell growth or stresses, different natural defenses are mobilized to maintain a steady state. However, infectious micro-organisms have evolved adaptive strategies to evade from this immune response. Similarly, cancer development results in part from tumor-induced immunosuppression and immune escape. Conversely, in the case of auto-immune diseases, the immune system itself is dysfunctional and overactivated in relation with yet unknown genetic and/or environmental causes. In organ or stem cell transplantation, uncontrolled immune activation leads to tissue damage or graft rejection. In all these situations, T lymphocytes are key elements to either maintain integrity through effector or regulatory functions, or to enhance pathogenicity.
Consequently, modulation of T cell activation is a general concern in the prevention or cure of various diseases including cancer, infections, autoimmune disorders, graft rejection or graft-versus-host disease. The delineation of the mechanisms underlying this activation is a prerequisite towards this goal. In this context, the global objective of our team since several years is to understand the cellular and molecular mechanisms of human T lymphocyte activation in normal or pathological conditions. A special focus is made on gamma-delta T lymphocytes, on autoimmune diseases and cancer two topics on which our members have developed an expertise, important tools and national and international collaborations since many years.
Our research aims to shed light on the question of how an immune response against foreign or self-antigens can lead to either protective immunity (against CMV or tumors or in surveillance of cell stress), to control of homeostasis (surveillance of tissue integrity) or to breakdown of tolerance (in autoimmunity or transplantation). Imental for optimal development of our studies.

PUBLICATIONS

2017

Monlun, M., Hyernard, C., Blanco, P., Lartigue, L.,  and B. Faustin (2017). “Mitochondria as Molecular Platforms Integrating Multiple Innate Immune Signalings.” J Mol Biol. Jan 6;429(1):1-13.

Khairallah, C., J. Dechanet-Merville and M. Capone (2017). “gammadelta T Cell-Mediated Immunity to Cytomegalovirus Infection.” Front Immunol 8: 105.

Furman, D., J. Chang, L. Lartigue, C. R. Bolen, F. Haddad, B. Gaudilliere, E. A. Ganio, G. K. Fragiadakis, M. H. Spitzer, I. Douchet, S. Daburon, J. F. Moreau, G. P. Nolan, P. Blanco, J. Dechanet-Merville, C. L. Dekker, V. Jojic, C. J. Kuo, M. M. Davis and B. Faustin (2017). “Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.” Nat Med 23(2): 174-184.

Visentin, J., T. Bachelet, C. Borg, N. Franchini, T. Nong, J. H. Lee, L. Couzi, P. Merville, G. Guidicelli and J. L. Taupin (2017). “Reassessment of T Lymphocytes Crossmatches Results Prediction With Luminex Class I Single Antigen Flow Beads Assay.” Transplantation 101(3): 624-630.

2016

Bachelet, T., J. Visentin, G. Guidicelli, P. Merville, L. Couzi and J. L. Taupin (2016). “Anti-HLA donor-specific antibodies are not created equally. Don’t forget the flow.” Transpl Int 29(4): 508-510.

Kaminski, H., L. Couzi, I. Garrigue, J. F. Moreau, J. Dechanet-Merville and P. Merville (2016). “Easier Control of Late-Onset Cytomegalovirus Disease Following Universal Prophylaxis Through an Early Antiviral Immune Response in Donor-Positive, Recipient-Negative Kidney Transplants.” Am J Transplant 16(8): 2384-2394.

Guidicelli, G., F. Guerville, S. Lepreux, C. Wiebe, O. Thaunat, V. Dubois, J. Visentin, T. Bachelet, E. Morelon, P. Nickerson, P. Merville, J. L. Taupin and L. Couzi (2016). “Non-Complement-Binding De Novo Donor-Specific Anti-HLA Antibodies and Kidney Allograft Survival.” J Am Soc Nephrol 27(2): 615-625.

Kaminski, H., I. Garrigue, L. Couzi, B. Taton, T. Bachelet, J. F. Moreau, J. Dechanet-Merville, R. Thiebaut and P. Merville (2016). “Surveillance of gammadelta T Cells Predicts Cytomegalovirus Infection Resolution in Kidney Transplants.” J Am Soc Nephrol 27(2): 637-645.

Loiseau, P., K. Amokhrane, J. Visentin, V. D. Kheav, S. Caillat-Zucman and J. L. Taupin (2016). “Use of Single-Antigen Flow Beads Assays to Assess Anti-HLA Donor-Specific Antibody Strength.” Biol Blood Marrow Transplant 22(2): 394-395.

Turpin, D., M. E. Truchetet, B. Faustin, J. F. Augusto, C. Contin-Bordes, A. Brisson, P. Blanco and P. Duffau (2016). “Role of extracellular vesicles in autoimmune diseases.” Autoimmun Rev 15(2): 174-183.

Visentin, J., L. Minder, J. H. Lee, J. L. Taupin and C. Di Primo (2016). “Calibration free concentration analysis by surface plasmon resonance in a capture mode.” Talanta 148: 478-485.

Visentin, J., G. Guidicelli, L. Couzi, P. Merville, J. H. Lee, C. Di Primo and J. L. Taupin (2016). “Deciphering IgM interference in IgG anti-HLA antibody detection with flow beads assays.” Hum Immunol.

Bachelet, T., P. Merville, J. Dechanet-Merville and L. Couzi (2016). “Cytomegalovirus-Induced gammadelta T Cells During Rejection: An Ambivalent T Cell.” Am J Transplant 16(1): 368-369.

Bachelet, T., C. Martinez, A. Del Bello, L. Couzi, S. Kejji, G. Guidicelli, S. Lepreux, J. Visentin, N. Congy-Jolivet, L. Rostaing, J. L. Taupin, N. Kamar and P. Merville (2016). “Deleterious Impact of Donor-Specific Anti-HLA Antibodies Toward HLA-Cw and HLA-DP in Kidney Transplantation.” Transplantation 100(1): 159-166.

Visentin, J., G. Guidicelli and J. L. Taupin (2016). “Are complement-fixing antibodies against denatured HLA antigens clinically relevant?” Exp Mol Pathol 100(3): 532-533.

Rey, C., B. Faustin, I. Mahouche, R. Ruggieri, C. Brulard, F. Ichas, I. Soubeyran, L. Lartigue and F. De Giorgi (2016). “The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer.” Oncogene 35(24): 3190-3200.

Visentin, J., T. Bachelet, C. Borg, N. Franchini, T. Nong, J. H. Lee, L. Couzi, P. Merville, G. Guidicelli and J. L. Taupin (2016). “Reassessment of T Lymphocytes Crossmatches Results Prediction With Luminex Class I Single Antigen Flow Beads Assay.” Transplantation.

Visentin, J., A. Chartier, L. Massara, G. Linares, G. Guidicelli, E. Blanchard, M. Parrens, H. Begueret, C. Dromer and J. L. Taupin (2016). “Lung intragraft donor-specific antibodies as a risk factor for graft loss.” J Heart Lung Transplant.

Visentin, J., D. Ramaharo, A. Ryman, C. Contin-Bordes and P. Merville (2016). “Prevalence of IgA Antibodies to beta2-Glycoprotein I: A Population-Dependent Feature?” Transplantation 100(3): e13-14.

Garcia-Beltran, W. F., A. Holzemer, G. Martrus, A. W. Chung, Y. Pacheco, C. R. Simoneau, M. Rucevic, P. A. Lamothe-Molina, T. Pertel, T. E. Kim, H. Dugan, G. Alter, J. Dechanet-Merville, S. Jost, M. Carrington and M. Altfeld (2016). “Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.” Nat Immunol 17(9): 1067-1074.

Khoryati, L., J. F. Augusto, E. Shipley, C. Contin-Bordes, I. Douchet, S. Mitrovic, M. E. Truchetet, E. Lazaro, P. Duffau, L. Couzi, C. Jacquemin, T. Barnetche, P. Vacher, T. Schaeverbeke, P. Blanco, C. Richez and A. Federation Hospitalo-Universitaire (2016). “IgE Inhibits Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Expression of Interferon-alpha by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.” Arthritis Rheumatol 68(9): 2221-2231.

2015

Couzi, L., V. Pitard, J. F. Moreau, P. Merville and J. Dechanet-Merville (2015). “Direct and Indirect Effects of Cytomegalovirus-Induced gammadelta T Cells after Kidney Transplantation.” Front Immunol 6: 3.

Kabelitz, D. and J. Dechanet-Merville (2015). “Editorial: “Recent Advances in Gamma/Delta T Cell Biology: New Ligands, New Functions, and New Translational Perspectives”.” Front Immunol 6: 371.

Viot, B., I. Garrigue, B. Taton, T. Bachelet, J. F. Moreau, J. Dechanet-Merville, P. Merville and L. Couzi (2015). “Two-year post-transplantation cytomegalovirus DNAemia in asymptomatic kidney transplant recipients: incidence, risk factors, and outcome.” Transpl Infect Dis 17(4): 497-509.

Visentin, J., G. Guidicelli and J. L. Taupin (2015). “Assessing HLA Antibody Strength: Have We Thought About Everything?” Am J Transplant 15(12): 3271.

Sicard, A., S. Ducreux, M. Rabeyrin, L. Couzi, B. McGregor, L. Badet, J. Y. Scoazec, T. Bachelet, S. Lepreux, J. Visentin, P. Merville, V. Fremeaux-Bacchi, E. Morelon, J. L. Taupin, V. Dubois and O. Thaunat (2015). “Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss.” J Am Soc Nephrol 26(2): 457-467.

Bonneville, M., Z. W. Chen, J. Dechanet-Merville, M. Eberl, J. J. Fournie, J. M. Jameson, R. D. Lopez, M. Massaia and B. Silva-Santos (2015). “Chicago 2014–30 years of gammadelta T cells.” Cell Immunol 296(1): 3-9.

Couzi, L., R. Perera, M. Manook, A. N. Barnett, O. Shaw, N. Kessaris, S. D. Marks, A. Dorling and N. Mamode (2015). “Incidence and Outcome of C4d Staining With Tubulointerstitial Inflammation in Blood Group-incompatible Kidney Transplantation.” Transplantation 99(7): 1487-1494.

Visentin, J., G. Guidicelli, J. F. Moreau, J. H. Lee and J. L. Taupin (2015). “Deciphering allogeneic antibody response against native and denatured HLA epitopes in organ transplantation.” Eur J Immunol 45(7): 2111-2121.

Jacquemin, C., N. Schmitt, C. Contin-Bordes, Y. Liu, P. Narayanan, J. Seneschal, T. Maurouard, D. Dougall, E. S. Davizon, H. Dumortier, I. Douchet, L. Raffray, C. Richez, E. Lazaro, P. Duffau, M. E. Truchetet, L. Khoryati, P. Mercie, L. Couzi, P. Merville, T. Schaeverbeke, J. F. Viallard, J. L. Pellegrin, J. F. Moreau, S. Muller, S. Zurawski, R. L. Coffman, V. Pascual, H. Ueno and P. Blanco (2015). “OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.” Immunity 42(6): 1159-1170.

Kolev, M., S. Dimeloe, G. Le Friec, A. Navarini, G. Arbore, G. A. Povoleri, M. Fischer, R. Belle, J. Loeliger, L. Develioglu, G. R. Bantug, J. Watson, L. Couzi, B. Afzali, P. Lavender, C. Hess and C. Kemper (2015). “Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.” Immunity 42(6): 1033-1047.

Khairallah, C., S. Netzer, A. Villacreces, M. Juzan, B. Rousseau, S. Dulanto, A. Giese, P. Costet, V. Praloran, J. F. Moreau, P. Dubus, D. Vermijlen, J. Dechanet-Merville and M. Capone (2015). “gammadelta T cells confer protection against murine cytomegalovirus (MCMV).” PLoS Pathog 11(3): e1004702.

Bachelet, T., C. Nodimar, J. L. Taupin, S. Lepreux, K. Moreau, D. Morel, G. Guidicelli, L. Couzi and P. Merville (2015). “Intravenous immunoglobulins and rituximab therapy for severe transplant glomerulopathy in chronic antibody-mediated rejection: a pilot study.” Clin Transplant 29(5): 439-446.

Guerville, F., S. Daburon, R. Marlin, L. Lartigue, S. Loizon, V. Pitard, L. Couzi, J. F. Moreau, J. Dechanet-Merville and B. Faustin (2015). “TCR-dependent sensitization of human gammadelta T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance.” Oncoimmunology 4(5): e1003011.

Visentin, J., M. Marroc, G. Guidicelli, T. Bachelet, T. Nong, J. F. Moreau, J. H. Lee, P. Merville, L. Couzi and J. L. Taupin (2015). “Clinical impact of preformed donor-specific denatured class I HLA antibodies after kidney transplantation.” Clin Transplant 29(5): 393-402.

Kaminski, H., L. Couzi, J. Dechanet-Merville and P. Merville (2015). “[Immunomonitoring for cytomegalovirus infection in kidney transplantation: Development and prospects].” Nephrol Ther 11(6): 465-473.

Petitpierre, F., F. Cornelis, L. Couzi, A. S. Lasserre, E. Tricaud, Y. Le Bras, P. Merville, C. Combe, J. M. Ferriere and N. Grenier (2015). “Embolization of renal arteries before transplantation in patients with polycystic kidney disease: a single institution long-term experience.” Eur Radiol 25(11): 3263-3271.

Queruel, V., R. Kabore, A. Guillaume, K. Moreau, K. Leffondre, L. Couzi, A. Quinart, J. Rogier, P. Tauzin-Fin, P. Merville, G. Robert, G. Pasticier, H. Bensadoun, J. Ferriere and J. Bernhard (2015). “[Not Available].” Prog Urol 25(13): 764-765.

Couzi, L., M. Manook, R. Perera, O. Shaw, Z. Ahmed, N. Kessaris, A. Dorling and N. Mamode (2015). “Difference in outcomes after antibody-mediated rejection between abo-incompatible and positive cross-match transplantations.” Transpl Int 28(10): 1205-1215.

Guenot, M., S. Loizon, J. Howard, G. Costa, D. A. Baker, S. Y. Mohabeer, M. Troye-Blomberg, J. F. Moreau, J. Dechanet-Merville, O. Mercereau-Puijalon, M. Mamani-Matsuda and C. Behr (2015). “Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vgamma9Vdelta2 T Cells.” Infect Immun 83(10): 3816-3824.

Krzywinska, E., N. Allende-Vega, A. Cornillon, D. N. Vo, L. Cayrefourcq, C. Panabieres, C. Vilches, J. Dechanet-Merville, Y. Hicheri, J. F. Rossi, G. Cartron and M. Villalba (2015). “Identification of Anti-tumor Cells Carrying Natural Killer (NK) Cell Antigens in Patients With Hematological Cancers.” EBioMedicine 2(10): 1364-1376.

Neau-Cransac, M., B. Le Bail, G. Guidicelli, J. Visentin, K. Moreau, A. Quinart, A. Boueilh, C. Laurent and J. L. Taupin (2015). “Evolution of serum and intra-graft donor-specific anti-HLA antibodies in a patient with two consecutive liver transplantations.” Transpl Immunol 33(2): 58-62.

Visentin, J., G. Guidicelli, T. Nong, J. F. Moreau, P. Merville, L. Couzi, J. H. Lee and J. L. Taupin (2015). “Evaluation of the iBeads assay as a tool for identifying class I HLA antibodies.” Hum Immunol 76(9): 651-656.

2016

Gensous, N., N. Schmitt, C. Richez, H. Ueno and P. Blanco (2016). “T follicular helper cells, interleukin-21 and systemic lupus erythematosus.” Rheumatology (Oxford).

Blanco, P., H. Ueno and N. Schmitt (2016). “T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis.” Eur J Immunol 46(2): 281-290.

Contis, A., H. Vanquaethem, M. E. Truchetet, L. Couzi, C. Rigothier, C. Richez, E. Lazaro and P. Duffau (2016). “Analysis of the effectiveness and safety of rituximab in patients with refractory lupus nephritis: a chart review.” Clin Rheumatol 35(2): 517-522.

Schaeverbeke, T., M. E. Truchetet, M. Kostine, T. Barnetche, B. Bannwarth and C. Richez (2016). “Immunogenicity of biologic agents in rheumatoid arthritis patients: lessons for clinical practice.” Rheumatology (Oxford) 55(2): 210-220.

Turpin, D., M. E. Truchetet, B. Faustin, J. F. Augusto, C. Contin-Bordes, A. Brisson, P. Blanco and P. Duffau (2016). “Role of extracellular vesicles in autoimmune diseases.” Autoimmun Rev 15(2): 174-183.

Kostine, M., O. Lichtwitz, M. E. Truchetet and N. Leveziel (2016). “Choroidal osteoma: Bone in the eye.” Joint Bone Spine 83(4): 454.

Poissonnier, A., D. Sanseau, M. Le Gallo, M. Malleter, N. Levoin, R. Viel, L. Morere, A. Penna, P. Blanco, A. Dupuy, F. Poizeau, A. Fautrel, J. Seneschal, F. Jouan, J. Ritz, E. Forcade, N. Rioux, C. Contin-Bordes, T. Ducret, A. M. Vacher, P. A. Barrow, R. J. Flynn, P. Vacher and P. Legembre (2016). “CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice.” Immunity 45(1): 209-223.

Schmitt, N., Y. Liu, S. E. Bentebibel and H. Ueno (2016). “Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans.” Cell Rep 16(4): 1082-1095.

Darrigade, A. S., A. L. Vedie, C. Gauthier, M. Cario-Andre, A. Taieb, M. E. Truchetet, J. Constans and J. Seneschal (2016). “Pigmented skin patches without scleroderma as a predominant clinical symptom revealing systemic sclerosis.” Clin Exp Dermatol 41(4): 379-382.

Scherlinger, M., T. Schaeverbeke, P. Blanco and C. Richez (2016). “A unilateral erosive arthritis in a patient with systemic lupus erythematosus.” Joint Bone Spine.

Truchetet, M. E., N. Poursac, T. Barnetche, E. Shipley, J. E. Gottenberg, B. Bannwarth, C. Richez and T. Schaeverbeke (2016). “Abatacept monotherapy compared with abatacept plus disease-modifying anti-rheumatic drugs in rheumatoid arthritis patients: data from the ORA registry.” Arthritis Res Ther 18: 72.

Bentebibel, S. E., S. Khurana, N. Schmitt, P. Kurup, C. Mueller, G. Obermoser, A. K. Palucka, R. A. Albrecht, A. Garcia-Sastre, H. Golding and H. Ueno (2016). “ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination.” Sci Rep 6: 26494.

Truchetet, M. E., B. Demoures, J. Eduardo Guimaraes, A. Bertrand, P. Laurent, V. Jolivel, I. Douchet, C. Jacquemin, L. Khoryati, P. Duffau, E. Lazaro, C. Richez, J. Seneschal, M. S. Doutre, J. L. Pellegrin, J. Constans, T. Schaeverbeke, P. Blanco, C. Contin-Bordes and A. Federation Hospitalo-Universitaire (2016). “Platelets Induce Thymic Stromal Lymphopoietin Production by Endothelial Cells: Contribution to Fibrosis in Human Systemic Sclerosis.” Arthritis Rheumatol 68(11): 2784-2794.

Brembilla, N. C., A. M. Dufour, M. Alvarez, S. Hugues, E. Montanari, M. E. Truchetet, P. Lonati, L. Fontao, A. Gabrielli, S. Vettori, G. Valentini, W. H. Boehncke, P. Meroni and C. Chizzolini (2016). “IL-22 capacitates dermal fibroblast responses to TNF in scleroderma.” Ann Rheum Dis 75(9): 1697-1705.

Khoryati, L., J. F. Augusto, E. Shipley, C. Contin-Bordes, I. Douchet, S. Mitrovic, M. E. Truchetet, E. Lazaro, P. Duffau, L. Couzi, C. Jacquemin, T. Barnetche, P. Vacher, T. Schaeverbeke, P. Blanco, C. Richez and A. Federation Hospitalo-Universitaire (2016). “IgE Inhibits Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Expression of Interferon-alpha by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.” Arthritis Rheumatol 68(9): 2221-2231.

Puges, M., P. Biscay, T. Barnetche, M. E. Truchetet, C. Richez, J. Seneschal, N. Gensous, E. Lazaro and P. Duffau (2016). “Immunogenicity and impact on disease activity of influenza and pneumococcal vaccines in systemic lupus erythematosus: a systematic literature review and meta-analysis.” Rheumatology (Oxford) 55(9): 1664-1672.

Lazaro, E., M. Scherlinger, M. E. Truchetet, L. Chiche, T. Schaeverbeke, P. Blanco and C. Richez (2016). “Biotherapies in systemic lupus erythematosus: New targets.” Joint Bone Spine.

2014-2015

Bentebibel, S. E., C. Jacquemin, N. Schmitt and H. Ueno (2015). “Analysis of human blood memory T follicular helper subsets.” Methods Mol Biol 1291: 187-197.

Raffray, L., I. Douchet, J. F. Augusto, J. Youssef, C. Contin-Bordes, C. Richez, P. Duffau, M. E. Truchetet, J. F. Moreau, C. Cazanave, L. Leroux, G. Mourrissoux, F. Camou, B. Clouzeau, P. Jeannin, Y. Delneste, C. Gabinski, O. Guisset, E. Lazaro and P. Blanco (2015). “Septic shock sera containing circulating histones induce dendritic cell-regulated necrosis in fatal septic shock patients.” Crit Care Med 43(4): e107-116.

Cornelis, F., M. E. Truchetet, N. Amoretti, D. Verdier, C. Fournier, O. Pillet, O. Gille and O. Hauger (2014). “Bisphosphonate therapy for unresectable symptomatic benign bone tumors: a long-term prospective study of tolerance and efficacy.” Bone 58: 11-16.

Schmitt, N. and H. Ueno (2015). “Regulation of human helper T cell subset differentiation by cytokines.” Curr Opin Immunol 34: 130-136.

Jacquemin, C., N. Schmitt, C. Contin-Bordes, Y. Liu, P. Narayanan, J. Seneschal, T. Maurouard, D. Dougall, E. S. Davizon, H. Dumortier, I. Douchet, L. Raffray, C. Richez, E. Lazaro, P. Duffau, M. E. Truchetet, L. Khoryati, P. Mercie, L. Couzi, P. Merville, T. Schaeverbeke, J. F. Viallard, J. L. Pellegrin, J. F. Moreau, S. Muller, S. Zurawski, R. L. Coffman, V. Pascual, H. Ueno and P. Blanco (2015). “OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.” Immunity 42(6): 1159-1170.

Richez, C., M. E. Truchetet, T. Schaeverbeke and B. Bannwarth (2014). “Atacicept as an investigated therapy for rheumatoid arthritis.” Expert Opin Investig Drugs 23(9): 1285-1294.

Schmitt, N., Y. Liu, S. E. Bentebibel, I. Munagala, L. Bourdery, K. Venuprasad, J. Banchereau and H. Ueno (2014). “The cytokine TGF-beta co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells.” Nat Immunol 15(9): 856-865.

Schmitt, N., S. E. Bentebibel and H. Ueno (2014). “Phenotype and functions of memory Tfh cells in human blood.” Trends Immunol 35(9): 436-442.

Bertrand, A., M. Kostine, T. Barnetche, M. E. Truchetet and T. Schaeverbeke (2015). “Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis.” BMC Med 13: 211.

2016

Alizadeh, D. and N. Larmonier (2016). “Generation and Expansion of T Helper 17 Lymphocytes Ex Vivo.” Methods Mol Biol 1371: 101-113.

Stokes, J., E. A. Hoffman, Y. Zeng, N. Larmonier and E. Katsanis (2016). “Post-transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation.” Br J Haematol 174(1): 102-116.

Yin, W., L. Gorvel, S. Zurawski, D. Li, L. Ni, D. Duluc, K. Upchurch, J. Kim, C. Gu, R. Ouedraogo, Z. Wang, Y. Xue, H. Joo, J. P. Gorvel, G. Zurawski and S. Oh (2016). “Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells.” EBioMedicine 5: 46-58.

Yin, W., D. Duluc, H. Joo, Y. Xue, C. Gu, Z. Wang, L. Wang, R. Ouedraogo, L. Oxford, A. Clark, F. Parikh, S. Kim-Schulze, L. Thompson-Snipes, S. Y. Lee, C. Beauregard, J. H. Woo, S. Zurawski, A. G. Sikora, G. Zurawski and S. Oh (2016). “Therapeutic HPV Cancer Vaccine Targeted to CD40 Elicits Effective CD8+ T-cell Immunity.” Cancer Immunol Res 4(10): 823-834.

2014-2015

Duluc, D., R. Banchereau, J. Gannevat, L. Thompson-Snipes, J. P. Blanck, S. Zurawski, G. Zurawski, S. Hong, J. Rossello-Urgell, V. Pascual, N. Baldwin, J. Stecher, M. Carley, M. Boreham and S. Oh (2014). “Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments.” Genome Med 6(11): 98.

Janikashvili, N., T. Chikovani, S. Audia, B. Bonnotte and N. Larmonier (2015). “T Lymphocyte Plasticity in Autoimmunity and Cancer.” Biomed Res Int 2015: 540750.

Majeed, B. A., L. S. Eberson, S. Tawinwung, N. Larmonier, T. W. Secomb and D. F. Larson (2015). “Functional aortic stiffness: role of CD4(+) T lymphocytes.” Front Physiol 6: 235.

Majeed, B., S. Tawinwung, L. S. Eberson, T. W. Secomb, N. Larmonier and D. F. Larson (2014). “Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening.” Int J Hypertens 2014: 126365.

Hanke, N. T., C. J. LaCasse, C. B. Larmonier, D. Alizadeh, M. Trad, N. Janikashvili, B. Bonnotte, E. Katsanis and N. Larmonier (2014). “PIAS1 and STAT-3 impair the tumoricidal potential of IFN-gamma-stimulated mouse dendritic cells generated with IL-15.” Eur J Immunol 44(8): 2489-2499.

Parikh, F., D. Duluc, N. Imai, A. Clark, K. Misiukiewicz, M. Bonomi, V. Gupta, A. Patsias, M. Parides, E. G. Demicco, D. Y. Zhang, S. Kim-Schulze, J. Kao, S. Gnjatic, S. Oh, M. R. Posner and A. G. Sikora (2014). “Chemoradiotherapy-induced upregulation of PD-1 antagonizes immunity to HPV-related oropharyngeal cancer.” Cancer Res 74(24): 7205-7216.

Alizadeh, D., M. Trad, N. T. Hanke, C. B. Larmonier, N. Janikashvili, B. Bonnotte, E. Katsanis and N. Larmonier (2014). “Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer.” Cancer Res 74(1): 104-118.

Alizadeh, D., E. Katsanis and N. Larmonier (2014). “Chemotherapeutic targeting of myeloid-derived suppressor cells.” Oncoimmunology 3(1): e27359.

Janikashvili, N., M. Trad, A. Gautheron, M. Samson, B. Lamarthee, F. Bonnefoy, S. Lemaire-Ewing, M. Ciudad, K. Rekhviashvili, F. Seaphanh, B. Gaugler, S. Perruche, A. Bateman, L. Martin, S. Audia, P. Saas, N. Larmonier and B. Bonnotte (2015). “Human monocyte-derived suppressor cells control graft-versus-host disease by inducing regulatory forkhead box protein 3-positive CD8+ T lymphocytes.” J Allergy Clin Immunol 135(6): 1614-1624 e1614.

Duluc, D., H. Joo, L. Ni, W. Yin, K. Upchurch, D. Li, Y. Xue, P. Klucar, S. Zurawski, G. Zurawski and S. Oh (2014). “Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1.” J Immunol 192(12): 5776-5788.

Alizadeh, D. and N. Larmonier (2014). “Chemotherapeutic targeting of cancer-induced immunosuppressive cells.” Cancer Res 74(10): 2663-2668.

Joo, H., D. Li, M. Dullaers, T. W. Kim, D. Duluc, K. Upchurch, Y. Xue, S. Zurawski, R. Le Grand, Y. J. Liu, M. Kuroda, G. Zurawski and S. Oh (2014). “C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.” Immunity 41(4): 592-604.

Miot, C., E. Beaumont, D. Duluc, H. Le Guillou-Guillemette, L. Preisser, E. Garo, S. Blanchard, I. Hubert Fouchard, C. Creminon, P. Lamourette, I. Fremaux, P. Cales, F. Lunel-Fabiani, J. Boursier, O. Braum, H. Fickenscher, P. Roingeard, Y. Delneste and P. Jeannin (2015). “IL-26 is overexpressed in chronically HCV-infected patients and enhances TRAIL-mediated cytotoxicity and interferon production by human NK cells.” Gut 64(9): 1466-1475.

2016
2015

To be completed